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It becomes the tipping point that overwhelms a nervous system already compromised by earlier events

presented a heterozygous CHAC1 deletion mouse model that was protected from kidney disease progression across three different disease models, without any known phenotypic changes under control conditions ( Despite its injury-promoting effects in some organs, CHAC1 contributes to tissue repair in certain contexts

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Paneco, 135), while the other part was seeded on plastic plates (Corning) and cultured for no longer than 8 passages in RPMI growth medium (Paneco, 330) supplemented with 10% FBS, 2 mM glutamine (Gibco, #35050061), 1% penicillin/streptomycin (Paneco, A065), and 1% non-essential amino acids (Paneco, 115/100)